魔芋提取物的皮肤保护功效及机理研究

詹鸿伟; ZHAN Hongwei; 陈晓燕; CHEN Xiaoyan; 黄颖琦; HUANG Yingqi; 何昊恩; HE Haoen; 詹雅娴; ZHAN Yaxian; 杜先华; DU Xianhua; 陈鸿娟; CHEN Hongjuan

doi:10.48014/atcm.20251223001

魔芋提取物的皮肤保护功效及机理研究

Research on Skin Protective Effects and Mechanisms of Konjac Extract

中医药研究进展 2026年第2卷第2期页码[23-31] 下载全文[2.1MB]

摘要

目的通过探究魔芋乙醇提取物对皮肤的保护作用, 验证魔芋是否适用于化妆品功能性原料开发。方法开展对魔芋的吸湿性能、保湿性能、体外抗氧化能力、细胞毒性、HaCaT细胞光保护作用和抑制黑色素作用等相关实验, 对各项实验所得数据展开系统性的统计与分析。结果采用干燥器控湿法对样品的吸湿性能进行测定: 透明质酸>魔芋>壳聚糖; 保湿性 (48h) : 魔芋>壳聚糖≈透明质酸; 体外抗氧化实验表明魔芋乙醇提取物的DPPH 清除率高达80%, 显著高于维生素E; 魔芋乙醇提取物对HaCaT细胞未见毒性作用, 且能显著修复UV 诱导的细胞损伤并提升存活率; 此外, 该提取物能通过下调其酪氨酸酶活性, 从而有效抑制B16F10细胞的黑色素合成。结论魔芋乙醇提取物具有低毒性、长效保湿、抗氧化、优异的光保护及美白等诸多保护皮肤的功效, 适用于化妆品功能性原料开发。

Abstract

Objective To explore the protective effects of ethanol extract of Amorphophallus konjac on the skin and verify whether konjac is suitable for developing functional raw materials for cosmetics. Methods Experiments were conducted to evaluate the moisture absorption, moisture retention, in vitro antioxidant capacity, cytotoxicity, photoprotective effect on HaCaT cells, and melanin inhibition effect of konjac. All experimental data were systematically statistically analyzed. Results The hygroscopicity was measured by the method of controlling humidity through a dryer: hyaluronic acid>konjac>chitosan; the moisturizing property ( 48h) : konjac>chitosan≈hyaluronic acid; the in vitro antioxidant experiment showed that the DPPH scavenging rate of konjac ethanol extract wasl 80%, which was significantly higher than that of Vitamin E; Konjac ethanol extract was non-toxic to HaCaT cells and could significantly repair UV-induced cell damage and increase cell survival rate; Konjac ethanol extract significantly inhibited melanin production and tyrosinase activity in B16F10 cells. Conclusion The konjac ethanol extract exhibits multiple skin-protective effects such as low toxicity, long-lasting moisturization, antioxidant activity, excellent photoprotection and skin whitening. It is suitable for the development of functional raw materials in cosmetics.

DOI

10.48014/atcm.20251223001

文章类型

研究性论文

收稿日期

2025-12-23

接收日期

2026-03-27

出版日期

2026-06-28

关键词

魔芋, 皮肤保护, 化妆品

Keywords

Konjac, skin protection, cosmetics

作者

詹鸿伟¹, 陈晓燕², 黄颖琦², 何昊恩², 詹雅娴², 杜先华², 陈鸿娟^3,*

Author

ZHAN Hongwei¹, CHEN Xiaoyan², HUANG Yingqi², HE Haoen², ZHAN Yaxian², DU Xianhua², CHEN Hongjuan^3,*

所在单位

1. 广州中医药大学第八临床医学院, 广州 510006
2. 广州中医药大学中药学院岭南中药资源教育部重点实验室, 广州 510006
3. 中山大学附属第一医院药学部, 广州 510080

Company

1. The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, China
2. Key Laboratory of Chinese Medicinal Resource from Lingnan, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
3. Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

浏览量

下载量

基金项目

广州中医药大学科技成果孵化项目(资助号GZYFH2025Z01)

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引用本文

詹鸿伟, 陈晓燕, 黄颖琦, 等. 魔芋提取物的皮肤保护功效及机理研究[J]. 中医药研究进展, 2026, 2(2): 23-31.

Citation

ZHAN Hongwei, CHEN Xiaoyan, HUANG Yingqi, et al. Research on Skin Protective Effects and Mechanisms of Konjac Extract[J]. Advances in Traditional Chinese Medicine, 2026, 2(2): 23-31.