3D打印PVDF/PLA/BTO压电椎间融合器及性能表征

高国庆; GAO Guoqing; 张昊; ZHANG Hao; 桑琳; SANG Lin; 董旭峰; DONG Xufeng

doi:10.48014/pcms.20250420002

3D打印PVDF/PLA/BTO压电椎间融合器及性能表征

3D Printing and Performance Characterization of PVDF/PLA/BTO Piezoelectric Intervertebral Fusion Cages

中国材料科学进展 2025年第4卷第4期页码[66-74] 下载全文[3.4MB]

摘要

本研究旨在探讨电刺激对骨愈合的促进作用, 并提出一种将压电聚合物聚偏氟乙烯 (PVDF) 应用于椎间融合器的新方法。通过3D打印技术, 依据患者CT影像实现个性化设计。为增强PVDF的压电性能, 掺入3%质量分数的钛酸钡 (BTO) 粉末, 并添加15%的聚乳酸 (PLA) 以改善热膨胀性能和流动性。研究发现, 随着填充率从40%增至70%, 压电信号强度减弱, 但抗压缩性能提升。在60%填充率下, 该装置在承受100N压力时产生397mV的压电信号, 且抗压强度达34. 55MPa。结果表明, 60%填充率为最佳选择, 优化后的椎间融合器具有优异的压电及力学性能, 为个性化医疗提供了新途径。

Abstract

This study aims to investigate the promotive effect of bone healing through electrical stimulation and proposes a novel method of applying the piezoelectric polymer polyvinylidene fluoride (PVDF) in intervertebral fusion devices. Utilizing 3D printing technology, personalized designs are achieved based on patient CT images. To enhance the piezoelectric properties of PVDF, barium titanate (BTO) powder at 3% mass fraction is incorporated, along with 15% polylactic acid (PLA) to improve the thermal expansion performance and flowability. The study found that as the filling rate increased from 40% to 70%, the piezoelectric signal strength decreased, but the compressive strength improved. At a 60% filling rate, the device produced a 397 mV piezoelectric signal under a 100N load and exhibited a compressive strength of 34. 55 MPa. The results indicate that a 60% filling rate is the optimal choice, demonstrating that the optimized intervertebral fusion device possesses excellent piezoelectric and mechanical properties, which provides a new approach for personalized medicine.

DOI

10.48014/pcms.20250420002

文章类型

研究性论文

收稿日期

2025-04-20

接收日期

2025-04-25

出版日期

2025-12-28

关键词

3D打印, 压电聚合物, 椎间融合器, 聚偏氟乙烯, 聚乳酸

Keywords

3D printing, piezoelectric polymer, intervertebral fusion cage, polyvinylidene fluoride, polylactic acid

作者

高国庆¹, 张昊², 桑琳^1,2, 董旭峰^1,*

Author

GAO Guoqing¹, ZHANG Hao², SANG Lin^1,2, DONG Xufeng^1,*

所在单位

1. 大连理工大学材料科学与工程学院, 大连 116024
2. 大连理工大学附属中心医院 (大连市中心医院) 骨科, 大连 116033

Company

1. School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, China
2. Department of Orthopedics, Dalian University of Technology Affiliated Central Hospital (Dalian Central Hospital) , Dalian 116033, China

浏览量

下载量

基金项目

大连市优秀青年科技人才项目(2023RY022);大连市生命健康领域指导计划项目(2023ZXYG14)

参考文献

[1] Shangguan L, Ning G Z, Tang Y, et al. Discover cervical disc arthroplasty versus anterior cervical discectomy and fusion in symptomatic cervical disc diseases: A meta-analysis[J]. PLoS One, 2017, 12(3): e0174822.
http://doi.org/10.1371/journal.pone.0174822
[2] Muss L, Wilmskoetter J, Richter K, et al. Changes in Swallowing After Anterior Cervical Discectomy and Fusion With Instrumentation: A Presurgical Versus Postsurgical Videofluoroscopic Comparison[J]. J Speech Lang Hear Res, 2017, 60(4): 785-793.
http://doi.org/10.1044/2016_jslhr-s-16-0091
[3] 王迎军, 杜昶, 赵娜如, 等. 仿生人工骨修复材料研究 [J]. 华南理工大学学报(自然科学版), 2012, 40(10): 51-58.
http://doi.org/10.3969/j.issn.1000-565X.2012.10.007
[4] 吴仲恺. 牙周骨移植材料研究进展 [J]. 中国实用口腔科杂志, 2012, 5(02): 120-123.
[5] Lasanianos N G, Kanakaris N K, Giannoudis P V. Current management of long bone large segmental defects[J]. Orthopaedics and Trauma, 2010, 24(2): 149-163.
https://doi.org/10.1016/j.mporth.2009.10.003
[6] Kurtz S M, Devine J N. PEEK biomaterials in trauma, orthopedic, and spinal implants[J]. Biomaterials, 2007, 28(32): 4845-4869.
http://doi.org/10.1016/j.biomaterials.2007.07.013
[7] Korovessis P, Repantis T, Vitsas V, et al. Cervical spondylodiscitis associated with oesophageal perforation: a rare complication after anterior cervical fusion[J]. Eur J Orthop Surg Traumatol, 2013, 23 Suppl 2: S159-63.
http://doi.org/10.1007/s00590-012-1092-y
[8] Barbosa F, Garrudo F F F, Alberte P S, et al. Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering[J]. Sci Technol Adv Mater, 2023, 24(1): 2242242.
http://doi.org/10.1080/14686996.2023.2242242
[9] Roldan L, Montoya C, Solanki V, et al. A Novel Injectable Piezoelectric Hydrogel for Periodontal Disease Treatment[J]. ACS Appl Mater Interfaces, 2023, 15(37): 43441-43454.
http://doi.org/10.1021/acsami.3c08336
[10] Deng B G, Wang Y H, Wu Y F, et al. Raman Nanotags- Guided Intraoperative Sentinel Lymph Nodes Precise Location with Minimal Invasion[J]. Advanced Science, 2022, 9(2).
http://doi.org/10.1002/advs.202102405
[11] Liu Y, Tian H, Hu Y, et al. Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing[J]. Int J Biol Sci, 2022, 18(10): 3961-3980.
http://doi.org/10.7150/ijbs.71390
[12] Srirussamee K, Mobini S, Cassidy N J, et al. Direct electrical stimulation enhances osteogenesis by inducing Bmp2 and Spp1 expressions from macrophages and preosteoblasts[J]. Biotechnology and Bioengineering, 2019, 116(12): 3421-3432.
http://doi.org/10.1002/bit.27142
[13] Panda P K. Review: environmental friendly lead-free piezoelectric materials[J]. Journal of Materials Science, 2009, 44(19): 5049-5062.
http://doi.org/10.1007/s10853-009-3643-0
[14] Rodrigues M T, Gomes M E, Mano J F, et al. β-PVDF Membranes Induce Cellular Proliferation and Differentiation in Static and Dynamic Conditions[J]. Materials Science Forum, 2008, 587-588: 72-76.
http://doi.org/10.4028/www.scientific.net/MSF.587-588.72
[15] Damaraju S M, Wu S, Jaffe M, et al. Structural changes in PVDF fibers due to electrospinning and its effect on biological function[J]. Biomedical Materials, 2013, 8(4).
http://doi.org/10.1088/1748-6041/8/4/045007
[16] Pärssinen J, Hammarén H, Rahikainen R, et al. Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride)[J]. Journal of Biomedical Materials Research Part A, 2015, 103(3): 919-928.
https://doi.org/10.1002/jbm.a.35234
[17] Ribeiro C, Sencadas V, Correia D M, et al. Piezoelectric polymers as biomaterials for tissue engineering applications[J]. Colloids and Surfaces B: Biointerfaces, 2015, 136: 46-55.
https://doi.org/10.1016/j.colsurfb.2015.08.043
[18] Damaraju S M, Shen Y, Elele E, et al. Three-dimensional piezoelectric fibrous scaffolds selectively promote mesenchymal stem cell differentiation[J]. Biomaterials, 2017, 149: 51-62.
http://doi.org/10.1016/j.biomaterials.2017.09.024
[19] Kang S J, Park Y J, Sung J, et al. Spin cast ferroelectricbeta poly(vinylidene fluoride)thin films via rapid thermalannealing[J]. Applied Physics Letters, 2008, 92(1).
http://doi.org/10.1063/1.2830701
[20] Sajkiewicz P, Wasiak A, Gocłowski Z. Phase transitionsduring stretching of poly(vinylidene fluoride)[J]. EuropeanPolymer Journal, 1999, 35(3): 423-429.
https://doi.org/10.1016/S0014-3057(98)00136-0
[21] Sencadas V, R. G J, AND Lanceros-Méndez S. α to βPhase Transformation and Microestructural Changes ofPVDF Films Induced by Uniaxial Stretch[J]. Journalof Macromolecular Science, Part B, 2009, 48(3): 514-525.
http://doi.org/10.1080/00222340902837527
[22] Zhang Y Y, Jiang S L, Yu Y, et al. Phase transformationmechanisms and piezoelectric properties of poly(vinylidene fluoride)/montmorillonite composite[J]. Journal of Applied Polymer Science, 2012, 123(5): 2595-2600.
https://doi.org/10.1002/app.34431
[23] Neumann G, Bihler E, Eberle G, et al. Polarization distributionin PVDF obtained by poling under constant current condition; proceedings of the Annual Conferenceon Electrical Insulation and Dielectric Phenomena, F 28-31 Oct. 1990, 1990[C].
https://doi.org/10.1109/CEIDP.1990.201326
[24] Nilsson E, Lund A, Jonasson C, et al. Poling and characterizationof piezoelectric polymer fibers for use intextile sensors[J]. Sensors and Actuators A: Physical, 2013, 201: 477-486.
https://doi.org/10.1016/j.sna.2013.08.011
[25] Gao H, Minh P T, Wang H, et al. High-performanceflexible yarn for wearable piezoelectric nanogenerators[J]. Smart Materials and Structures, 2018, 27(9).
http://doi.org/10.1088/1361-665X/aad718
[26] Bodkhe S, Rajesh P S M, Kamle S, et al. Beta-phase enhancementin polyvinylidene fluoride through filler addition: comparing cellulose with carbon nanotubes andclay[J]. Journal of Polymer Research, 2014, 21(5): 434.
http://doi.org/10.1007/s10965-014-0434-3
[27] Rajesh P S M, Bodkhe S, Kamle S, et al. Enhancing beta-phase in PVDF through physicochemical modificationof cellulose[J]. Electronic Materials Letters, 2014, 10(1): 315-319.
http://doi.org/10.1007/s13391-013-3083-5
[28] Huang Z X, Li L W, Huang Y Z, et al. Self-poled piezoelectricpolymer composites via melt-state energy implantation[J]. Nature Communications, 2024, 15(1).
http://doi.org/10.1038/s41467-024-45184-4
[29] Bencomo J A, Iacono S T, Mccollum J. 3D printingmultifunctional fluorinated nanocomposites: tuningelectroactivity, rheology and chemical reactivity[J]. Journal of Materials Chemistry A, 2018, 6(26): 12308-12315.
http://doi.org/10.1039/C8TA00127H
[30] Liu Y, Chen X, Wang L, et al. Surface charge of PLAmicroparticles in regulation of antigen loading, macrophagephagocytosis and activation, and immune effects[J]. Particuology, 2014, 17: 74-80.
http://doi.org/10.1016/j.partic.2014.02.006
[31] Salehiyan R, Ray S S, Ojijo V. Processing-Driven MorphologyDevelopment and Crystallization Behavior ofImmiscible Polylactide/Poly(Vinylidene Fluoride)Blends[J]. Macromolecular Materials and Engineering, 2018, 303(10).
http://doi.org/10.1002/mame.201800349
[32] Wang B, Huang H-X. Incorporation of halloysite nanotubesinto PVDF matrix: Nucleation of electroactivephase accompany with significant reinforcement and dimensionalstability improvement[J]. Composites Parta-Applied Science and Manufacturing, 2014, 66: 16-24.
http://doi.org/10.1016/j.compositesa.2014.07.001
[33] Nakagawa K, Ishida Y. Estimation of amorphous specificvolume of poly(vinylidene fluoride)as a function oftemperature[J]. Kolloid-Zeitschrift and Zeitschrift FurPolymere, 1973, 251(2): 103-107.
http://doi.org/10.1007/bf01498933
[34] Chu L, Li R, Liao Z, et al. Highly Effective Bone FusionInduced by the Interbody Cage Made of Calcium Silicate/Polyetheretherketone in a Goat Model[J]. ACSBiomater Sci Eng, 2019, 5(5): 2409-2416.
http://doi.org/10.1021/acsbiomaterials.8b01193

引用本文

高国庆, 张昊, 桑琳, 等. 3D打印PVDF/PLA/BTO压电椎间融合器及性能表征[J]. 中国材料科学进展, 2025, 4(4): 66-74.

Citation

GAO Guoqing, ZHANG Hao, SANG Lin, et al. 3D printing and performance characterization of PVDF/PLA/BTO piezoelectric intervertebral fusion cages[J]. Progress in Chinese Materials Sciences, 2025, 4(4): 66-74.