Picasso' s Cubist collage is a kind of hybrid work in which heterogeneous elements (“ready-made” colored paper, printed text, etc. ) are pasted onto canvas, and the two elements of “paste” and “painting” are established and complement each other. At present, domestic and foreign Picasso' s Cubist collage research and media theory related monographs are quite abundant, and on the premise that scholars in the 20th century have connected art history and media theory, the research materials of McLuhan' s discussion with art history are also relatively abundant. However, from the perspective of “collage as a technique of artistic creation”, there are relatively few studies that purely analyze its operation mechanism and reasons, and discuss how it influences the integration of heterogeneous elements in Picasso' s collage works. Therefore, this paper firstly reviews a brief history of art historical research on Cubist collage from the different perspectives of early critics to modern scholars, and then briefly summarizes McLuhan' s views on Cubism and Picasso, and explores their significance in depth with the help of examples. Based on this media theory perspective, this paper analyzes two specific works in Picasso' s Cubist collage, and finally uncovers the artistic value of Cubist collage as a medium———it not only changes the artist' s way of creation, but also influences the audience' s way of observation and feeling of the world, and opens up a new possibilities.