Based on the author's theory and methodology of Seismo-Geothermics, and utilizing data from ANSS earthquake catalog (California Earthquake Center USA) , this paper investigates the genesis mechanism and predictive approach for the M7. 9 earthquake that struck Mandalay, Myanmar, on March 28, 2025, and briefly outlines the fundamental structure, characteristics and strong controlling influence of the No. 17 Myanmar Seismic Cone Tectonic. This paper examines the seismic background of the Mandalay region, the spatiotemporal distribution patterns of sub-crustal seismicity, the chronological features of deeper seismic events, the M-t (magnitude-time) diagrams for both crustal and sub-crustal earthquakes, and their relationship with crustal structure, and introduces a basic framework for the prediction of strong crustal earthquakes and potential volcanic eruptions, providing a reference for the predictive studies of strong earthquakes and volcanic eruptions in 24 seismic cone tectonics zones worldwide. To evaluate the practical effectiveness of the Seismo-Geothermics theory, three global maps of sub-crustal seismic activity are presented.