The 14th Five-year-Plan Period is the “Five Period Overlapping” for the transformation and upgrading, high-quality development, and sustainable development of natural resources in Tibet, that means critical period, promotion period, transformation period, deepening period, and tackling period. In view of the new situation faced by the protection and utilization of natural resources, in the coming period, Tibet will focus on the problem of unbalanced and inadequate development based on its natural resources endowment, and actively play a supporting role of natural resources to strengthen the firm national and ecological security barriers. This article describes the current situation of the protection and utilization of natural resources in Tibet, cites typical cases, analyzes opportunities and challenges, and explores the significance and general requirements for the optimal development of natural resource protection and utilization in Tibet. It also puts forward the development direction of natural resources protection and utilization in Tibet from six aspects, which include ecological civilization construction, conservation and intensive utilization of natural resources, accelerating the construction of strategic mineral resources reserve bases, optimizing the spatial pattern of national territory, improving prevention and control system of geological disaster, and deepening the reforms in the field of natural resources. It aims to contribute natural resources to the high-quality development of Tibet, and provide powerful natural resources support and guarantee for serving “Four Foundations” of Tibet.